Consumption of anti-meticillin-resistant Staphylococcus aureus antibiotics in Swiss hospitals is associated with antibiotic stewardship measures

BackgroundConsumption of antibiotics active against meticillin-resistant Staphylococcus aureus (MRSA) has been described in numerous European studies. However, the underlying predictors consumption are still poorly understood.AimTo describe anti-MRSA (daptomycin, intravenous glycopeptides, linezolid) Switzerland over time and to identify predictor variables.MethodsA retrospective observational multi-centre study was conducted 21 Swiss hospitals a period 11 years (2009–2019). Multiple linear regression models were built regional hospital-specific variables affecting antibiotics.FindingsConsumption increased between 2009 2019 from 12.7 24.5 defined daily doses per 1000 bed-days (+93%). In first model presented, which includes data whole period, following associated with higher antibiotic consumption: number MRSA cases (P < 0.01), year hospital type (tertiary care university vs others, P department (intensive unit 0.01) linguistic region (French German Italian, 0.01). second including query on policies place 2019, presence an stewardship group prescription restrictions antibiotics.ConclusionOur shows that both implementation restrictions, i.e. factors can be controlled by itself, lower antibiotics. Consumption understood. To variables. A Our